Irisin ameliorates bone loss in ovariectomized mice.
Conclusion: Irisin increases osteoblasts and decreases the number of osteoclasts, which leads to the maintenance of bone mass and quality in OVX mice. Irisin likely preserves the bone microarchitecture via building a 'new balance'. Therefore, our study extended the understanding of the role of irisin in bone metabolism and revealed the possibility of therapeutic application of irisin for postmenopausal osteoporosis.
PMID: 32319323 [PubMed - as supplied by publisher]
Source: Climacteric - Category: Geriatrics Authors: Luo Y, Ma Y, Qiao X, Zeng R, Cheng R, Nie Y, Li S, A R, Shen X, Yang M, Xu CC, Xu L Tags: Climacteric Source Type: research