circRNA_001275 upregulates Wnt7a expression by competitively sponging miR ‑370‑3p to promote cisplatin resistance in esophageal cancer.

In conclusion, the present study revealed that circRNA_001275 was upregulated in cisplatin‑resistant esophageal cancer and promoted cisplatin resistance by sponging miR‑370‑3p to upregulate Wnt7a expression. Therefore, circRNA_001275 may serve as a potential diagnostic biomarker and therapeutic target for patients with cisplatin‑resistant esophageal cancer.
PMID: 32319613 [PubMed - as supplied by publisher]

Source: International Journal of Oncology - April 21, 2020 Category: Cancer & Oncology Authors: Zou FW, Yang SZ, Li WY, Liu CY, Liu XH, Hu CH, Liu ZH, Xu S Tags: Int J Oncol Source Type: research