Cytokine-Encapsulated Biodegradable Microspheres for Immune Therapy.

Cytokine-Encapsulated Biodegradable Microspheres for Immune Therapy. Immunol Invest. 2020 Apr 22;:1-16 Authors: Egilmez NK Abstract Therapeutic macromolecules such as proteins are conventionally administered via bolus injection, an approach that presents significant limitations. Sustained-release biodegradable nano/microsphere depots, on the other hand, represent a more physiological delivery tool for biologics. Here, we focus on an emerging novel application of this technology, i.e., cytokine-encapsulated biodegradable microspheres as immune therapeutics. The overall pre-clinical experience, recent advances and the clinical potential of such formulations are discussed. PMID: 32316775 [PubMed - as supplied by publisher]
Source: Immunological Investigations - Category: Allergy & Immunology Tags: Immunol Invest Source Type: research