Characterization of Sperm of White Rats at Exposure of Bisphenol A and Triclosan

We studied the effect of unstable ubiquitous endocrine disruptors (bisphenol A and triclosan) on the reproductive function of mature male Wistar rats. Animals of both experimental groups received bisphenol A and triclosan (homogeneity>97%) in a dose of 200 mg/kg daily for 2 months with food. The concentrations of disruptors were measured directly in the testicular tissue by gas chromatography with mass spectrometry (GC-MS). In both experimental groups, the concentrations of bisphenol A and triclosan in the testicular tissue significantly differed from the control (intact animals). Animals exposed to bisphenol A significantly differed by sperm parameters (total number, motility, and sperm morphology) from control rats. Animals receiving triclosan significantly differed from control rats only by the number of actively motile spermatozoa and the weight of the testicles.

Source: Bulletin of Experimental Biology and Medicine - April 22, 2020 Category: Biology Source Type: research