Use of the kinetically-derived maximum dose concept in selection of top doses for toxicity studies hampers proper hazard assessment and risk management

Publication date: Available online 22 April 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Minne B. Heringa, Nicole H.P. Cnubben, Wout Slob, Marja E.J. Pronk, Andre Muller, Marjolijn Woutersen, Betty C. Hakkert
Source: Regulatory Toxicology and Pharmacology - Category: Toxicology Source Type: research