Deletion of dpy-19 like 2 (DPY19L2) gene is associated with total but not partial globozoospermia.

Deletion of dpy-19 like 2 (DPY19L2) gene is associated with total but not partial globozoospermia. Reprod Fertil Dev. 2020 Apr 21;: Authors: Alimohammadi F, Ebrahimi Nasab M, Rafaee A, Hashemi M, Totonchi M, Mohseni Meybodi A, Sadighi Gilani MA, Sabbaghian M Abstract The dpy-19 like 2 (DPY19L2) gene is the most common genetic cause of globozoospermia characterised by the production of round-headed spermatozoa without an acrosome. The present study was performed on 63 men with globozoospermia and 41 normozoospermic individuals to evaluate the frequency of the DPY19L2 gene and exons; deletion and genetic changes in exons 1, 5, 7-11, 19, 21 and interval introns; and some epidemiological factors (e.g. varicocele, smoking, drug use, alcohol consumption and a family history of infertility). Homozygous deletion of DPY19L2 was identified in 35% of men with globozoospermia. Exon 7 was deleted in 4.8% of men with globozoospermia in which DPY19L2 was not deleted. No genetic variations were observed within the DPY19L2 exons examined, but five intronic polymorphisms were detected: 1054-77T>C in intron 9, 1131+65T>C and 1131+53A>G in intron 10 and 1218+22T>C and 1218+73T>C in intron 11. There were significant differences in the frequency of 1054-77T>C and 1218+22T>C polymorphisms between the globozoospermic and normozoospermic groups. In addition, there were significant differences between the two groups in sperm count, sperm motility, a history o...
Source: Reproduction, Fertility, and Development - Category: Reproduction Medicine Authors: Tags: Reprod Fertil Dev Source Type: research

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Infertility may be associated with severe psychological burden and many couples need mental support. We used dyadic approach to identify couples with disturbed psychological condition and we tested the WHO-5 Well-Being Index (WHO-5-WBI) questionnaire as a possible, rapid screening method. Extensive psychological assessment of infertile couples was carried out with Beck ’s Depression Inventory, Spielberger State-Trait Anxiety Inventory, WHO-5-WBI, Symptom Check List-90 Revised Test, Fagerstrom Test for Nicotine Dependence, Alcohol Use Disorders Identification Test. Data of 128 patients (64 couples) were used in the st...
Source: Psychologica Belgica - Category: Psychiatry & Psychology Source Type: research
This study aimed to explore the association of serum 25 ‐hydroxyvitamin D (25OHD) levels and semen parameters, as well as ART outcomes for men from infertile couples.Materials and MethodsThis study recruited 1,308 men from infertile couples who attended the Reproductive Medicine Center of Peking University Third Hospital for first time from February to August 2019(NCT03804294). Reproductive hormones levels, semen parameters and clinical outcomes of ART were compared between vitamin D deficient group (serum 25OHD ≤10 ng/mL), insufficient group (serum 25OHD 10‐20 ng/mL) and sufficient group (serum 25OHD≥20 ng/mL).R...
Source: Andrology - Category: Urology & Nephrology Authors: Tags: ORIGINAL ARTICLE Source Type: research
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Source: Journal of Racial and Ethnic Health Disparities - Category: International Medicine & Public Health Source Type: research
In conclusion, although cigarette smoking does not seem to affect oocyte development, it had an effect on cytoplasmic anomalies and therefore may lower pregnancy chance. Therefore, it is crucial to give proper counselling to patients who are trying to become pregnant both naturally and by in vitro fertilization. PMID: 32338250 [PubMed - as supplied by publisher]
Source: Zygote - Category: Reproduction Medicine Authors: Tags: Zygote Source Type: research
Abstract BACKGROUND: Parabens, which are used as a preservative in foods and personal care products, are detected in nearly 100% of human urine samples. Exposure to parabens is associated with DNA damage, male infertility, and endocrine disruption in adults, but the effects of prenatal exposure are unclear. In part, this is due to inadequate assessment of exposure in maternal urine, which may only reflect maternal rather than fetal exposure. To address this gap, we examined the association of prenatal methylparaben measured in meconium with preterm birth, gestational age, birthweight, maternal thyroid hormones, an...
Source: Environment International - Category: Environmental Health Authors: Tags: Environ Int Source Type: research
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Source: Systems Biology in Reproductive Medicine - Category: Reproduction Medicine Authors: Tags: Syst Biol Reprod Med Source Type: research
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Source: Indian Journal of Pharmaceutical Sciences - Category: Drugs & Pharmacology Source Type: research
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Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research
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Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
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Source: Chinese Medical Journal - Category: General Medicine Authors: Tags: Chin Med J (Engl) Source Type: research
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