Could Gout Drug Colchicine Help Fight Severe COVID-19?

WEDNESDAY, April 22, 2020 -- As researchers hunt for ways to treat severe COVID-19 infections, a new trial will ask whether an old arthritis drug can prevent serious complications in the first place. The medication, called colchicine, is an oral...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news

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AbstractCurrent data demonstrated that severe cases of coronavirus-disease-19 (COVID-19) require treatment with antiviral therapy, dexamethasone, supportive care, as well as some anti-rheumatic drugs, among them, cytokine inhibitors and colchicine. Colchicine is an anti-inflammatory drug that is being used in rheumatology for many years to treat mostly gout, calcium pyrophosphate deposition disease, and Familial Mediterranean Fever. Here, we present for the first time, two patients suffering from gout being treated with colchicine, who were affected from severe acute respiratory coronavirus-2 (SARS-CoV-2) syndrome. Both pa...
Source: Rheumatology International - Category: Rheumatology Source Type: research
Conditions:   Systemic Lupus Erythematosus;   Sjogren's Syndrome;   Inflammatory Myositis;   Psoriatic Arthritis;   Gout;   Ankylosing Spondylitis;   Arthritis of Multiple Sites Associated With Inflammatory Bowel Disease (Diagnosis);   Osteoarthritis Intervention:   Biological: mRNA COVD19 vaccine Sponsor:   Mayo Clinic Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Hase R, Kurata R, Ishida K, Kurita T, Muranaka E, Mito H Abstract A 42-year-old man exhibiting hypoxia was diagnosed with coronavirus disease 2019. He had medical histories of type 2 diabetes, hyperlipidemia, hyperuricemia, and gout attack. He received favipiravir for compassionate use for 14 days. Subsequently, he showed increased uric acid levels and developed acute gouty arthritis. Favipiravir may induce not only hyperuricemia but also acute gouty arthritis. It should therefore be used with caution in patients with a history of gout and those with hyperuricemia, especially when used at a higher dose and...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
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