Phase 1 Trial of Concurrent Gemcitabine and Cisplatin with Image-Guided Intensity Modulated Radiation Therapy for Locoregionally Advanced Cervical Carcinoma

The use of concurrent doublet chemotherapy with radiation for locoregionally advanced cervical cancer (LACC) is limited by gastrointestinal and hematologic toxicity. By reducing radiation dose to bowel and bone marrow, image-guided intensity modulated radiation therapy (IG-IMRT) may improve chemotherapy tolerance. The goal of this study was to determine whether IG-IMRT could lead to improved tolerance to concurrent cisplatin and gemcitabine for LACC.

Source: International Journal of Radiation Oncology * Biology * Physics - April 21, 2020 Category: Radiology Authors: Loren K. Mell, Ronghui Xu, Catheryn M. Yashar, Michael T. McHale, John P. Einck, Jyoti Mayadev, Euyhyun Lee, Pratibha Binder, Dominique Rash, Ramez Eskander, Elena S. Heide, Steven C. Plaxe, Arno J. Mundt, Cheryl C. Saenz Source Type: research