Exercise Linked to Lower Breast Cancer Risk in Black Women

Regular, brisk activity seems to help prevent some aggressive tumors that resist hormone therapy, study says
Source: The Doctors Lounge - Oncology - Category: Cancer & Oncology Authors: Tags: Gynecology, Oncology, Research, Sports Medicine, News, Source Type: news

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DISCUSSION: For a diagnosis of primary breast cancer of the vulva, a thorough metastatic workup should be performed, with attention directed toward detecting a breast primary disease by results of the history, physical examination, and radiologic examination of the breasts mainly to help confirm that the vulvar lesion is the primary site as opposed to metastasis from a breast primary cancer and also for staging. Management of this rare entity is challenging because of a lack of specific guidelines, and treatment, therefore, is similar to that of breast cancer.Treatment should consist of an individualized combination of sur...
Source: The Permanente journal - Category: General Medicine Tags: Perm J Source Type: research
The objective of our study was to assess the co-prescription of CYP2D6 inhibitors and tamoxifen use and also to relate concomitant CYP2D6 inhibitor use and tamoxifen adherence to breast cancer in Riyadh, Saudi Arabia. All patients treated for breast cancer who had at least one tamoxifen prescription in their electronic medical records (EMRs) from June 2015 to June 2017 were included. Patients who had other adjuvant hormonal therapy were excluded from the study. In total, 499 patients (25 males and 474 females) with breast cancer using tamoxifen were included. Our study was purely observational study revealed...
Source: Saudi Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research
CONCLUSIONS: In this population-based study, aromatase inhibitors were associated with increased risks of heart failure and cardiovascular mortality compared with tamoxifen. There were also trends toward increased risks, although nonsignificant, of myocardial infarction and ischemic stroke. The increased risk of cardiovascular events associated with aromatase inhibitors should be balanced with their favorable clinical benefits compared with tamoxifen. PMID: 32065766 [PubMed - in process]
Source: Circulation - Category: Cardiology Authors: Tags: Circulation Source Type: research
ConclusionAdministration of adjuvant eribulin after neoadjuvant chemotherapy was feasible and well tolerated. The 24-month DFS rate did not reach the study target levels in any of the cohorts and was similar to DFS previously described in these cohorts following neoadjuvant chemotherapy alone.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
Targeted hypoxia ultrasonographic imaging presents an approach to dynamic surveillance of acquired antiestrogen therapeutic resistance in ER+ breast cancer. We established PLGA ‐PEG‐mAbCAIX nanobubbles and evaluated its conjunction with ultrasonographic imaging to accomplish these goals. The early tamoxifen resistance could be dynamically monitored by the noninvasive ultrasound NBs in patients, allowing for early intervention of tamoxifen resistance. AbstractTamoxifen ‐based hormone therapy is central for the treatment of estrogen receptor positive (ER+) breast cancer. However, the acquired tamoxifen resistance, typi...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
k Environmental and lifestyle factors are believed to account for >80% of breast cancers; however, it is not well understood how and when these factors affect risk and which exposed individuals will actually develop the disease. While alcohol consumption, obesity, and hormone therapy are some known risk factors for breast cancer, other exposures associated with breast cancer risk have not yet been identified or well characterized. In this paper, it is proposed that the identification of blood epigenetic markers for personal, in utero, and ancestral environmental exposures can help researchers better understand k...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
ConclusionWe have developed a consensus document with recommendations on the treatment of patients with HER2-negative luminal MBC that will help to improve therapeutic benefits.
Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsWe reported eight CpG sites as potential breast cancer prognosis signatures through comprehensively analyzed gene expression and DNA methylation datasets, and excluding influences of tumor stage and treatment. This should be helpful for breast cancer early diagnosis and treatment.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research
Current diagnosis and management of breast cancer relies primarily upon histology, clinical and pathologic staging, and a limited set of biomarkers for hormone therapy and anti-HER2 therapy. The principal biomarkers are estrogen receptor alpha (ER- α) (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER-2/neu, ERBB2). Pathologic work up of invasive tumors includes immunohistochemistry to evaluate for ER and PR expression, and immunohistochemistry and/or in situ hybridization (ISH) for determination of HER2 statu s.
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Source Type: research
This study investigated how a history of menopausal hormone therapy (MHT) impacts clinical outcomes overall and in different subgroups of breast cancer patients. The study included 814 primary breast cancer patients aged ≥50 years in Sweden (2002–2012) with follow-up until 2016. Associations between patient- and tumor characteristics, recurrences, and overall survival were analyzed in relation to MHT. After a median follow-up of 7 years, 119 recurrences, and 111 deaths occurred. Ever MHT (n = 433, 53.2%) was associated with a lower BMI, frequency of alcohol abstinence, and histological grade, higher frequency of o...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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