Diagnostic Accuracy of QuantiFERON-TB Gold Plus Assays in Children and Adolescents with Tuberculosis Disease

In 2016, a new interferon-gamma release assay, QuantiFERON-TB Gold Plus, was introduced. We conducted a cross-sectional multicenter study, involving 158 children and adolescents with tuberculosis disease. The overall sensitivity of the assay was 82.9% (IQR 77.0%-88.8%), indicating that in children this test does not have higher sensitivity than previous generation interferon-gamma release assays.

Source: The Journal of Pediatrics - April 21, 2020 Category: Pediatrics Authors: Aleix Soler-Garcia, Anna Gamell, Bego ña Santiago, Manuel Monsonís, Cristina Calvo, Elvira Cobo, Elena Colino, María Espiau, Carmelo Guerrero-Laleona, Zulema Lobato, Andrea Martín-Nalda, Beatriz Pérez-Gorricho, Tomas M. Perez-Porcuna, Ana Isabel Piqu Tags: Brief Reports Source Type: research