Singlet Oxygen Luminescence Image in Blood Vessels During Vascular ‐Targeted Photodynamic Therapy

In this study, the previously developed near ‐infrared (NIR) optical imaging system was optimized for fast imaging of1O2 luminescence. The optical imaging system enables direct imaging of1O2 luminescence in blood vessels within 2  s during vascular‐targeted PDT (V‐PDT), which makes this system extremely practical forin vivo studies. The dependence of RB concentration on1O2 luminescence image was investigated for V ‐PDT, and the data imply that 1270 nm signal is attributed to1O2 luminescence. The imaging system operates with a field of view of 9.60  × 7.68 mm2 and a spatial resolution of 30  μm, which holds the potential to elucidate the correlation between cumulative1O2 luminescence and vasoconstriction for V ‐PDT.
Source: Photochemistry and Photobiology - Category: Science Authors: Tags: Special Issue Research Article Source Type: research
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