Breast cancer drug 'halves likelihood of high-risk women developing disease'

Anastrozole must be made available on NHS immediately, say charities and authors of trial funded by Cancer Research UKA drug not yet available on the NHS has been found to be better at preventing breast cancer than those approved for use, leading to urgent calls for the National Institute for Health and Care Excellence to make it accessible immediately.The drug anastrozole has been found to halve the likelihood of high-risk women developing the disease and to have fewer side-effects, according to a study published on Thursday in the Lancet medical journal. The Ibis-II study, funded by Cancer Research UK and led by Queen Mary University of London, tracked almost 4,000 postmenopausal women at high risk of breast cancer and found that those who took anastrozole for five years were 53% less likely to develop the disease than women who took a placebo.Nice took the historic step this year of giving all women over 30 in England and Wales judged to be at moderate or high risk of breast cancer access to one of two drugs: tamoxifen or raloxifene. But the study suggests that neither is as effective as anastrozole and both had more side-effects.Professor Jack Cuzick, the lead researcherin the study, called it an "exciting development" in breast cancer prevention."We now know anastrozole should be the drug of choice when it comes to reducing the risk of breast cancer in postmenopausal women with a family history or other risk factors for the disease. This class of drugs is ...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: theguardian.com News Health Society Drugs The National Institute for Health and Care Excellence (Nice) UK news Breast cancer NHS Science Source Type: news

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Contributor : Yu ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDescription of breast cancer infiltrating lymphocyte through large scale single cell sequencing.While it has been well-recognized that T-cell mediated adaptive cellular immunity plays important roles in cancer immune response and tumor control, the roles of B lymphocytes in tumor development and therapy have only been proposed until recently, and are still mostly controversial. To gain mechanistic insights into the origin and dynamics of tumor infiltrated immune cells, especially B lymphocytes, we combined single ce...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Contributors : Heloisa H Milioli ; Neil PortmanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHere we characterise the response of models of ER-positive breast cancer to treatment with the small molecule MDM2 inhibitor NVP-CGM097, a dihydroisoquinolinone derivative currently evaluated in a phase I clinical trial. We show that NVP-CGM097 reduces tumour cell viability of in vitro and in vivo models of endocrine sensitive, endocrine resistant and palbociclib (CDK4/6 inhibitor) resistant p53 wildtype (p53wt) ER-positive breast cancer. NVP-CGM097 synergises with both fulvestrant and palbo...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Contributors : Wenfei Ji ; Fang YangSeries Type : Expression profiling by arrayOrganism : Homo sapiensAnalysis miRNA profiling of breast cancer cells treated without or with palbociclib.Results provide insight into the molecular mechanisms involved in resistance to pabbociclib.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Most women who are notified by mail that they have a high risk of breast cancer are unlikely to do anything about it, a small study suggests.Reuters Health Information
Source: Medscape Radiology Headlines - Category: Radiology Tags: Hematology-Oncology News Source Type: news
Conclusions: Reconstructive practices in a modern cohort of plastic surgeons suggest that immediate and implant reconstructions are performed preferentially. Respondents perceived a number of factors, including surgeon training, time spent in the operating room, and insurance reimbursement, to negatively influence the performance of autologous reconstruction.
Source: Plastic and Reconstructive Surgery - Category: Cosmetic Surgery Tags: Breast: Original Articles Source Type: research
Conclusion: Patients with moderate to severe breast ptosis and/or macromastia who wish to undergo mastectomy with reconstruction can be offered nipple-sparing approaches safely if a staged algorithm is implemented. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, IV.
Source: Plastic and Reconstructive Surgery - Category: Cosmetic Surgery Tags: Breast: Original Articles Source Type: research
The male reproductive hormone androgen may hold the key to a new treatment approach for estrogen receptor-positive breast cancer, the most common form of the disease, a new study has found.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
Condition:   Lymphedema, Breast Cancer Intervention:   Procedure: LYMPHA(LYmphatic Microsurgical Preventive Healing Approach) technique Sponsor:   Pusan National University Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Breast Cancer Interventions:   Diagnostic Test: Serum Autotaxin;   Radiation: chest x-ray;   Diagnostic Test: Breast ultrasound or mammography;   Diagnostic Test: Histopathological examination of breast mass specimens;   Radiation: Magnetic Resonance Imaging ( MRI) and Bone scan;   Diagnostic Test: Peripheral  haemogram;   Diagnostic Test: Renal and liver functions;   Diagnostic Test: Prothrombin time and concentration;   Diagnostic Test: Cancer Antigen...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
As the COVID-19 outbreak worsens in the U.S., at-home test kits for the virus have been a source of both hope and controversy. Their appeal is clear: sick individuals could get a diagnosis from the comfort of home, without infecting others. But their downsides are real: the U.S. Food and Drug Administration (FDA) has cracked down on unauthorized at-home COVID-19 tests, updating its emergency use authorization guidelines to exclude at-home test kits and warning Americans that no such tests have received agency authorization. That means startups previously offering these products—such as Everlywell, Nurx and Carbon Hea...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 Source Type: news
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