From pairs of most similar sequences to phylogenetic best matches.

Conclusion: Improvements of tree-free orthology assessment methods can be expected from a combination of the accurate inference of best matches reported here and recent mathematical advances in the understanding of (reciprocal) best match graphs and orthology relations.
Availability: Accompanying software is available at https://github.com/david-schaller/AsymmeTree.
PMID: 32308731 [PubMed]

Source: Algorithms for Molecular Biology : AMB - April 22, 2020 Category: Molecular Biology Authors: Stadler PF, Geiß M, Schaller D, López Sánchez A, González Laffitte M, Valdivia DI, Hellmuth M, Hernández Rosales M Tags: Algorithms Mol Biol Source Type: research