Oseltamivir and S-Adenosyl-L-Methionine Combination as Effective Therapeutic Strategy for Suppression of Oxidative Damage in Lung Caused by Influenza Virus Infection in Mice
Drug Res (Stuttg) DOI: 10.1055/a-1147-8824
Background and objectives The pathogenesis of influenza infection is
associated with two general processes in the body: (a) lung damage based on
virus replication; (b) overproduction of free radicals, antioxidant
deficiency, and development of oxidative stress. To attack these aspects of
flu pathogenesis, we explored the combined effect of the antiviral agent
oseltamivir, and s-adenosyl-l-methionine (SAM) as a precursor of the
endogenous antioxidant glutathione, in mice infected with influenza
virus.
Methods After inoculation of albino mice with 10 MLD50 of influenza
virus A/Aichi/2/68 (H3N2), oseltamivir was applied
twice a day, for five days post-infection in doses of 1.25 and 2.5
mg/kg. SAM was administered once a day for 10 days, starting 5 days
before infection in doses of 50, 100 and 150 mg/kg.
Results Monotherapy with SAM did not influence the markers of
oxidative stress in the lung. Combination of SAM 50 mg/kg and
oseltamivir 2.5 mg/kg affected best the virological parameters -
viral titer, protection index, and mean survival time, as well as the
biochemical markers of oxidative stress.
Interpretation and conclusions Combining of SAM and oseltamivir in a
dose of 1/4 of optimal therapeutic c...
Source: Drug Research - Category: Drugs & Pharmacology Authors: Mileva, Milka Dimitrova, Adriana Krastev, Dimo Alexandrova, Albena Tsvetanova, Elina Georgieva, Almira Galabov, Angel Tags: Original Article Source Type: research
More News: Antidoxidants | Drugs & Pharmacology | H3N2 | Influenza | Oseltamivir | Tamiflu | Virology