Pharmacokinetics and Safety of Posaconazole Tablet Formulation in Chinese Participants at High Risk for Invasive Fungal Infection

ConclusionIn Chinese AML patients, the posaconazole 300-mg tablet provided PK data comparable with those of previous studies and was generally well tolerated and efficacious.Clinical Trial RegistrationClinicalTrials.gov, NCT02387983.
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research

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AbstractBackground Patients with haematological malignancies are at high risk of invasive fungal infections. However, there is a lack of information about the utilisation of the recommended Australian antifungal prophylaxis guidelines in haematology outpatients.Objective To assess the impact of a weekly pharmacist review of high-risk adult haematology outpatients on the utilisation of appropriate antifungal prophylaxis.Setting Outpatient cancer centre, tertiary referral hospital in Sydney, Australia.Method A 3-month pre-and post-interventional study was conducted. A retrospective audit was conducted to obtain baseline util...
Source: International Journal of Clinical Pharmacy - Category: Drugs & Pharmacology Source Type: research
The aim of our study was to selectively analyze newly diagnosed acute myeloid leukemia patients treated with a hypomethylating agent and establish their risk for developing invasive fungal infections (IFI). We stratified patients into concern for IFI (cIFI) versus no concern, and observed that patients of the male gender and those with underlying chronic obstructive pulmonary disease (COPD) are at higher risk for cIFI, which may prompt clinicians to consider anti-mold prophylaxis in this setting.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Original Study Source Type: research
The aim of our study was to selectively analyze newly diagnosed patients with acute myeloid leukemia treated with a hypomethylating agent and establish their risk for developing invasive fungal infections (IFIs). We stratified patients into concern for IFI versus no concern, and observed that patients of the male gender and those with underlying chronic obstructive pulmonary disease are at higher risk for concern for IFI, which may prompt clinicians to consider anti-mold prophylaxis in this setting.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Original Study Source Type: research
Publication date: Available online 26 June 2020Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Jessie Signorelli, Matthew Lei, Jenna Lam, Marla Jalbut, Philip C. Amrein, Amir T. Fathi, Gabriela Hobbs, Hanno Hock, Steven Lawrence McAfee, Alyssa R. Letourneau, Rupa Narayan, Andrew Brunner
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
AbstractWith the advent of new targeted drugs in hematology and oncology patient prognosis is improved. Combination with antifungal prophylaxis challenges clinicians due to pharmacological profiles prone to drug –drug interactions (DDI). Midostaurin is a novel agent forFLT3-TKD/-ITDmut-acute myeloid leukemia (AML) and metabolized via cytochrome P450 3A4 (CYP3A4). Posaconazole is a standard of care antifungal agent used for prophylaxis during induction treatment of AML and a strong CYP3A4 inhibitor. Concomitant administration of both drugs leads to elevated midostaurin exposure. Both drugs improve overall survival at ...
Source: Annals of Hematology - Category: Hematology Source Type: research
To the Editor Dr Fisher and colleagues examined prevention of invasive fungal infections in neutropenic patients aged 3 months to 30 years with acute myeloid leukemia with caspofungin vs fluconazole. Caspofungin resulted in a statistically significant lower incidence of invasive fungal disease. However, prophylaxis depends on appropriateness and adequacy of the antifungal medication.
Source: JAMA - Category: General Medicine Source Type: research
Fusariosis is a fungal infection that affects immunocompromised hosts and is mainly fatal in its disseminated form. A 49-year-old male patient with acute myeloid leukemia, hepatic and splenic infiltration, thrombocytopenia, odynophagia, and abdominal pain was referred for evaluation. Clinical examination revealed nasal and small oral ulcers with erythematous halo on the soft palate, and diagnostic hypotheses were bacterial or viral infection. Treatment with cefepime and vancomycin, local hygiene, and low-level laser therapy were adopted, and lesions presented remission.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Source Type: research
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Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
In conclusion, twoDectin-1 SNPs (rs3901533 and rs7309123) are associated with increased susceptibility to pulmonary IFD in AML patients in a Chinese Han population.
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - Category: Research Source Type: research
Conference abstracts
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
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