Oocytes suppress FOXL2 expression in cumulus cells in mice.

In this study, we sought to identify key transcriptional regulators responsible for the differential gene expression between the two cell-lineages. In silico analysis of transcriptomic comparison between cumulus cells and MGCs identified several candidate regulators responsible for the diversification of the two cell-lineages. Among them, we herein focused on Forkhead box L2 (FOXL2) and showed that expression of FOXL2 as well as its target transcripts were differentially regulated between cumulus cells and MGCs. The lower expression of FOXL2 in cumulus cells seemed to be due to the suppression by oocyte-derived paracrine signals. These results suggest that FOXL2 is one of the critical transcription factors that determine cumulus cell and MGC lineages under the control of oocytes. PMID: 32307529 [PubMed - as supplied by publisher]
Source: Biology of Reproduction - Category: Reproduction Medicine Authors: Tags: Biol Reprod Source Type: research