Barusiban, a selective oxytocin receptor antagonist: placental transfer in rabbit, monkey, and human1.

In conclusion, limited placental transfer of barusiban occurred in all three models. The similarity of barusiban transfer in the cynomolgus and the human placental single cotyledon suggests the latter ex-vivo model to be useful in assessing future drug candidates to be used in pregnant women. PMID: 32307542 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32307542?dopt=Abstract

Source: Biology of Reproduction - April 17, 2020 Category: Reproduction Medicine Authors: Helmer H, Saleh L, Petricevic L, Knoefler M, Reinheimer TM Tags: Biol Reprod Source Type: research