Potential drug delivery nanosystems for improving tumor penetration.

Potential drug delivery nanosystems for improving tumor penetration.
Eur J Pharm Biopharm. 2020 Apr 17;:
Authors: Peng F, Li R, Zhang F, Qin L, Ling G, Zhang P
Abstract
Nanosystems, as one of the most important drug delivery systems, play a crucial rule in tumor therapy. However, the deep tumor penetration is retarded by the tumor physiological factors and nanomedicine properties. In this review, we firstly elaborate the factors which impact tumor penetration, including the tumor physiological factors and nanomedicine properties. Then, the latest and potential drug delivery nanosystems for improving tumor penetration are summarized and analyzed in detail. Moreover, recent combination therapies for improving penetration are described to enhance penetration. Finally, we summarize the typical clinical therapies of potential drug delivery nanosystems.
PMID: 32311427 [PubMed - as supplied by publisher]

Source: European Journal of Pharmaceutics and Biopharmaceutics - April 16, 2020 Category: Drugs & Pharmacology Authors: Peng F, Li R, Zhang F, Qin L, Ling G, Zhang P Tags: Eur J Pharm Biopharm Source Type: research