Screening for Novel LOX and SOD1 Variants in Keratoconus Patients from Brazil.

Conclusion: We described three novel LOX polymorphisms identified for the first time in Brazilian patients with advanced keratoconus, as well as a previously described SOD1 deletion strongly associated with keratoconus. A possible role of these variants in modulating transcript levels in the cornea of affected individual requires further investigation. PMID: 32308947 [PubMed]
Source: Journal of Ophthalmic and Vision Research - Category: Opthalmology Tags: J Ophthalmic Vis Res Source Type: research

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Condition:   IOP Readings Before and After Accelerated Corneal Collagen Crosslinking (CXL) Intervention:   Diagnostic Test: IOP Measurment Sponsor:   Fayoum University Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   The Reliability of Corneal Topographic Measurements of Keratoconus Eyes Intervention:   Diagnostic Test: corneal topography Sponsors:   Fayoum University;   Sara Tawfik Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Keratoconus Intervention:   Procedure: PKP Sponsor:   Alexandria University Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
We read with great interest the excellent article by Wang and associates.1 We recognize that intraocular lens power calculation in patients with keratoconus is challenging. Determining the accurate keratometry readings, axial length, and anterior chamber depth can be difficult in these eyes, which can lead to inaccurate and unpredictable results with a tendency to hyperopic refractive surprises.1 –4 To the best of our knowledge, this is the first study that reports the Barrett Universal II as the most accurate formula in mild keratoconus (stages I and II).
Source: American Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Correspondence Source Type: research
Condition:   Keratoconus Intervention:   Procedure: PKP Sponsor:   Alexandria University Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
The diagnosis of keratoconus in the early stages of the disease is necessary to initiate an early treatment of keratoconus. Furthermore, to avoid possible refractive surgery that could produce ectasias. This s...
Source: BMC Ophthalmology - Category: Opthalmology Authors: Tags: Research article Source Type: research
We appreciate the comments and inquiry from Gonzalez-Lubcke and associates. Intraocular lens (IOL) power calculations in eyes with keratoconus is indeed more unpredictable than in normal eyes using third and fourth-generation IOL formulas.
Source: American Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Correspondence Source Type: research
Meena Lakshmipathy, Prabhat Nangia, Rashima AsokanIndian Journal of Ophthalmology 2020 68(7):1459-1461 An 18-year-old girl who had undergone deep anterior lamellar keratoplasty in her left eye for keratoconus a year back presented with inferonasal graft dehiscence with intact host Descemet's membrane and intact anterior chamber after sustaining blunt injury a week prior. The graft was sutured to the host bed, and complete resolution of graft edema was seen in 4 weeks. One year later, she underwent cataract surgery with foldable intraocular lens implantation. At her final follow-up, the best-corrected visual acuity in ...
Source: Indian Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research
Anahita Kate, Joveeta Joseph, Bhupesh BaggaIndian Journal of Ophthalmology 2020 68(7):1463-1466 A 21-year-old boy underwent deep anterior lamellar keratoplasty (DALK) for advanced keratoconus. Postoperatively, slit lamp examination revealed multiple foci of interface infiltrates. Medical therapy was non-responsive, and therefore, a repeat lamellar transplantation was done. Scrapings were taken from host stroma and under the surface of the initial graft. Microbiological examination, aided by VITEK-2, revealed the causative organism as Kocuria kristinae. The postoperative course was uneventful and at a 1-year follow-up, the...
Source: Indian Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research
Molecules, Vol. 25, Pages 2933: Metabolomic Signature Discriminates Normal Human Cornea from Keratoconus—A Pilot GC/MS Study Molecules doi: 10.3390/molecules25122933 Authors: Anna Wojakowska Monika Pietrowska Piotr Widlak Dariusz Dobrowolski Edward Wylęgała Dorota Tarnawska The molecular etiology of keratoconus (KC), a pathological condition of the human cornea, remains unclear. The aim of this work was to perform profiling of metabolites and identification of features discriminating this pathology from the normal cornea. The combination of gas chromatography and mass spectrometry (GC/MS) techniqu...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
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