Biological plausibility for interactions between dietary fat, resveratrol, ACE2 and SARS-CoV illness severity.

Biological plausibility for interactions between dietary fat, resveratrol, ACE2 and SARS-CoV illness severity. Am J Physiol Endocrinol Metab. 2020 Apr 20;: Authors: Horne JR, Vohl MC Abstract The ACE2 cellular receptor is responsible for the pathogenesis of SARS-CoV, thus impacting the entrance and clearance of the virus. Studies demonstrate that upregulation of ACE2 has a protective effect on SARS-CoV-2 illness severity. Moreover, animal studies demonstrate that dietary intake can modulate ACE2 gene expression and function. A high intake of resveratrol may have a protective role, upregulating ACE2, whereas a high intake of dietary fat may have a detrimental role, downregulating ACE2. As such, we postulate on the biological plausibility of interactions between dietary fat and/or resveratrol and ACE2 gene variations in the modulation of SARS-CoV-2 illness severity. We call to action the research community to test this plausible interaction in a sample of human subjects. PMID: 32310688 [PubMed - as supplied by publisher]
Source: Am J Physiol Endocri... - Category: Endocrinology Authors: Tags: Am J Physiol Endocrinol Metab Source Type: research