Local ocular renin-angiotensin-aldosterone system (RAAS): any connection with intraocular pressure? A comprehensive review.

Local ocular renin-angiotensin-aldosterone system (RAAS): any connection with intraocular pressure? A comprehensive review. Ann Med. 2020 Apr 20;:1-30 Authors: Holappa M, Vapaatalo H, Vaajanen A Abstract The renin-angiotensin system (RAS) is one of the oldest and most extensively studied human peptide cascades, well-known for its role in regulating blood pressure. When aldosterone is included, RAAS is involved also in fluid and electrolyte homeostasis. There are two main axes of RAAS; 1. Angiotensin (1-7), angiotensin converting enzyme 2 and Mas receptor (ACE2-Ang(1-7)-MasR), 2. Angiotensin II, angiotensin converting enzyme 1 and angiotensin II type 1 receptor (ACE1-AngII-AT1R). In its entirety, RAAS comprises dozens of angiotensin peptides, peptidases and seven receptors. The first mentioned axis is known to counterbalance the deleterious effects of the latter axis. In addition to the systemic RAAS, tissue-specific regulatory systems have been described in various organs, evidence that RAAS is both an endocrine and an autocrine system. These local regulatory systems, such as the one present in the vascular endothelium, are responsible for long-term regional changes. A local RAAS and its components have been detected in many structures of the human eye. This review focuses on the local ocular RAAS in the anterior part of the eye, its possible role in aqueous humor dynamics and intraocular pressure as well as RAAS as a potential targe...
Source: Annals of Medicine - Category: Internal Medicine Tags: Ann Med Source Type: research