CD20-positive extranodal NK/T cell lymphoma: clinicopathologic and prognostic features

AbstractExtranodal natural killer (NK)/T cell lymphoma (ENKTCL) with aberrant CD20 expression is extremely rare. Here, we describe the clinicopathologic features of 11 CD20-positive ENKTCLs from three institutions in China along with a literature review. Membranous expression of CD20 was identified in 1.29% (11/851) of ENKTCLs. CD20-positive ENKTCLs primarily occurred in extra-nasal sites (72.2%, 13/18) rather than in the nasal cavity (27.8%, 5/18). Most evaluated patients (71.4%, 10/14) presented ENKTCL at advanced stage IV. The percentage of CD20-positive tumor cells ranged from 20 to 90%, and the CD20 staining intensity was dimmer in tumor cells than in normal B cells. Among four cases with multiple biopsies, three cases showed discordant expression of CD20 between the disseminated and primary lesions. All evaluated cases were negative for other B cell markers, including PAX5, CD79a, and CD19, except for one case that showed focally positive for CD79a. Patients with CD20-positive ENKTCL more frequently had advanced diseases (stage III/IV: 70% vs 17%,p = 0.001), with older age (median age at diagnosis: 60 years vs. 43.5 years,p = 0.006) and had inferior outcome (median survival: 18.7 moths vs 36.0 moths,p = 0.017) compared with CD20-negative cases. Four nonsynonymous single nucleotide variants (C >  T) and one stop-gain mutation (C >  T) in the exonic region of CD20 gene (MS4A1) were detected in one of seven cases with target region next-generatio...
Source: Virchows Archiv - Category: Pathology Source Type: research