Effect of Smoking on Outcomes of Allogeneic Transplantation: A Single-Center Analysis

Allogeneic hematopoietic cell transplantation (allo-HCT) is still associated with various complications despite advances in supportive care. Pulmonary complications such as bronchiolitis obliterans (BO), interstitial pneumonia (IP), and pulmonary infectious disease are fatal adverse events after allo-HCT [1-3]. The incidence of BO was reported to be 5.5%, and the estimated 5-year survival was 40% to 50% [1,4,5]. The incidence of invasive mold infection, which is one of the most common pulmonary infections in allo-HCT, was reported to be 8.5%, and the 12-week mortality was 58.6% [3].

Source: Biology of Blood and Marrow Transplantation - March 17, 2020 Category: Hematology Authors: Masaharu Tamaki, Hideki Nakasone, Masakatsu Kawamura, Shunto Kawamura, Junko Takeshita, Nozomu Yoshino, Yukiko Misaki, Kazuki Yoshimura, Shinpei Matsumi, Ayumi Gomyo, Aki Tanihara, Machiko Kusuda, Yu Akahoshi, Koji Kawamura, Shun-ichi Kimura, Shinichi Kak Source Type: research