Elevated levels of Extracellular Heat Shock Protein 72 (eHSP72) are positively correlated with insulin resistance in vivo and cause pancreatic {beta}-cell dysfunction and death in vitro
Conclusions: We demonstrated a positive correlation between eHSP72 and IR. In addition, we suggest that chronic eHSP72 exposure may mediate β-cell failure.
Source: Clinical Science - Category: Biomedical Science Authors: M Krause, K Keane, J Rodrigues-Krause, D Crognale, B Egan, G De Vito, C Murphy, P Newsholme Source Type: research