Human leukocyte antigen-G donor-recipient matching of the 14-base pair polymorphism protects against cancer after heart transplant

After a transplant, cancer is a leading cause of morbidity and mortality. Human leukocyte antigen-G (HLA-G) —an immune checkpoint molecule—reduces allograft rejection by dampening host immune responses. Reports suggest malignant cells utilize HLA-G to evade the immune system and promote cancer development. Our objective was to evaluate HLA-G donor-recipient polymorphism matching and development of can cer after a heart transplant.

Source: The Journal of Heart and Lung Transplantation - April 5, 2020 Category: Transplant Surgery Authors: Mitchell B. Adamson, Roberto V.P. Ribeiro, Frank Yu, Julieta Lazarte, Kyle Runeckles, Cedric Manlhiot, Vivek Rao, Diego H. Delgado Tags: ORIGINAL CLINICAL SCIENCE Source Type: research