Transcriptome analysis and functional characterization of cerebral organoids in bipolar disorder

ConclusionsOur studies in cerebral organoids from bipolar disorder showed dysregulation in genes involved in cell adhesion, immune signaling, and endoplasmic reticulum biology; implicated a central role for the GWAS hit NCAN in the biology of BPI; and showed evidence of deficits in neurotransmission.
Source: Genome Medicine - Category: Genetics & Stem Cells Source Type: research