Current status of normothermic ex-vivo perfusion of cardiac allografts.
Current status of normothermic ex-vivo perfusion of cardiac allografts.
Curr Opin Organ Transplant. 2020 Apr 16;:
Authors: Ragalie WS, Ardehali A
Abstract
PURPOSE OF REVIEW: Ex-vivo perfusion has emerged in recent years as an alternative to cold static preservation of organs harvested for transplant. Normothermic ex-vivo perfusion, the subject of this review, maintains the donor heart in a near physiologic state, and allows the transplant team to monitor and control perfusion to the organ prior to implantation. A growing body of evidence has established the safety and viability of this technique, which may improve on current standards of donor management.
RECENT FINDINGS: Following initial single-arm studies over a decade ago, ex-vivo perfusion has been studied in a prospective, randomized fashion in standard donor hearts (PROCEED II trial). The short and intermediate-term results demonstrated similar outcomes compared with cold storage with significantly shorter cold ischemic time. Since then, ex-vivo perfusion has been studied in extended-criteria donor hearts, first in observational studies, and currently in randomized, prospective fashion in the recently completed EXPAND-Heart trial, which is anticipated to be reported in 2020.
SUMMARY: Normothermic ex-vivo perfusion has an established literature base and holds promise for changing current practices of heart preservation. Results of forthcoming pivotal studies wil...
Source: Current Opinion in Organ Transplantation - Category: Transplant Surgery Authors: Ragalie WS, Ardehali A Tags: Curr Opin Organ Transplant Source Type: research
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