Monte Carlo track-structure for the radionuclide Copper-64: characterization of S-values, nanodosimetry and quantification of direct damage to DNA.

In conclusion, the results of the S-values show that the absorbed dose strongly depends on the distribution of the radionuclide in the cell, the dose being higher when 64Cu is internalized in the cell nucleus, which is reinforced by the nanodosimetric study by the presence of DNA DSBs attributable to the Auger electrons emitted during the decay of 64Cu. PMID: 32303013 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32303013?dopt=Abstract

Source: Physics in Medicine and Biology - April 16, 2020 Category: Physics Authors: Carrasco-Hernandez J, Ramos-Mendez J, Faddegon BA, Jalilian AR, Moranchel M, Ávila-Rodríguez MÁ Tags: Phys Med Biol Source Type: research