Age-Dependent Progression in Lung Pathophysiology can be Prevented by Restoring Fatty Acid and Ceramide Imbalance in Cystic Fibrosis

ConclusionOur results demonstrate a progressive age-dependent decline in lung function inCftr KO mice. Treatment with LAU-7b corrects the lipid imbalance observed in the aging KO and WT mice and, more importantly, inhibits the age-dependent deterioration in lung physiology and histopathology.

Source: Lung - April 17, 2020 Category: Respiratory Medicine Source Type: research