Inactivation of Wt1 causes pre-granulosa cell to steroidogenic cell transformation and defect of ovary development.

This study demonstrates that Wt1 is required for lineage maintenance of granulosa cells and inactivation of Wt1 results in pre-granulosa cells to steroidogenic cells transformation which in turn causes the defect of ovary development. PMID: 32301970 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32301970?dopt=Abstract

Source: Biology of Reproduction - April 16, 2020 Category: Reproduction Medicine Authors: Cen C, Chen M, Zhou J, Jiang L, Hou X, Gao F Tags: Biol Reprod Source Type: research