Genomic Landscape of Uterine Sarcomas Defined through Prospective Clinical Sequencing.

CONCLUSIONS: Prospective genomic profiling can contribute to diagnostic precision and inform treatment selection in patients with uterine sarcomas. There was evidence of clinical benefit in uLMS patients with somatic BRCA2 alterations treated with PARP inhibitors.
PMID: 32299819 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - April 15, 2020 Category: Cancer & Oncology Authors: Hensley ML, Chavan SS, Solit DB, Murali R, Soslow R, Chiang S, Jungbluth AA, Bandlamudi C, Srinivasan P, Tap WD, Rosenbaum E, Taylor BS, Donoghue MTA, Hyman DM Tags: Clin Cancer Res Source Type: research