Chronic corticosterone shifts effort-related choice behavior in male mice

ConclusionsChronic stress induces maladaptive shifts in effort-related choice behavior in the Y-maze barrier task in male mice. Furthermore, males subjected to chronic CORT administration show reduced lever pressing in FR30/chow sessions where lab chow is concurrently available. These data demonstrate that chronic corticosterone reduces motivation to work for and obtain a highly rewarding reinforcer when a lesser reinforcer is concurrently available.

Source: Psychopharmacology - April 17, 2020 Category: Psychiatry Source Type: research