Strategies to Facilitate Translational Advances from Microbiome Surveys.

Strategies to Facilitate Translational Advances from Microbiome Surveys.
Trends Microbiol. 2020 May;28(5):329-330
Authors: Willis AD, Minot SS
Abstract
Manipulating the microbiome has enormous potential to treat important human diseases. Microbiome surveys are often used to identify potential therapeutic targets by finding associations between microbial elements and disease status. We argue that many reported associations between the microbiome and disease are incompatible with translational research because they are insufficiently specific. We encourage the clear specification of manipulable microbial elements that can be tested in follow-up randomized experiments, and we provide multiple examples of specific and nonspecific microbial elements.
PMID: 32298611 [PubMed - in process]

Source: Trends in Microbiology - April 18, 2020 Category: Microbiology Authors: Willis AD, Minot SS Tags: Trends Microbiol Source Type: research