Understanding the functional discrepancy of Pim-1 in cancer.

Understanding the functional discrepancy of Pim-1 in cancer. Front Biosci (Elite Ed). 2015;7:239-47 Authors: Ouhtit A, Muzumdar S, Gupta I, Shanmuganathan S, Tamimi Y Abstract The Pim-1 gene encodes for a proto-oncogenic serine/threonine protein kinase and is generally involved in cytokine signaling as well as in various signaling pathways regulating cell cycle and apoptosis. Pim-1 kinase plays a role in the development of various tumors mainly, prostate cancer, Burkitt's lymphoma, oral cancer and various other hematopoietic lymphomas. This review will focus on the importance and mechanisms of Pim-1 in prostate cancer and the potential clinical relevance of its various inhibitors. PMID: 25553374 [PubMed - in process]
Source: Frontiers in Bioscience - Elite - Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research