Understanding the functional discrepancy of Pim-1 in cancer.
Understanding the functional discrepancy of Pim-1 in cancer.
Front Biosci (Elite Ed). 2015;7:239-47
Authors: Ouhtit A, Muzumdar S, Gupta I, Shanmuganathan S, Tamimi Y
Abstract
The Pim-1 gene encodes for a proto-oncogenic serine/threonine protein kinase and is generally involved in cytokine signaling as well as in various signaling pathways regulating cell cycle and apoptosis. Pim-1 kinase plays a role in the development of various tumors mainly, prostate cancer, Burkitt's lymphoma, oral cancer and various other hematopoietic lymphomas. This review will focus on the importance and mechanisms of Pim-1 in prostate cancer and the potential clinical relevance of its various inhibitors.
PMID: 25553374 [PubMed - in process]
Source: Frontiers in Bioscience - Elite - Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research
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