Pharmacological inhibition of Transient Receptor Potential Melastatin 2 (TRPM2) Channels Attenuates Diabetes-induced Cognitive Deficits in Rats: A Mechanistic Study.

CONCLUSION: This study confirms the ameliorative effect of TRPM2 channel inhibitor in the diabetes-induced cognitive deficits. Inhibition of TRPM2 channels reduces the calcium associated downstream signaling and showed a neuroprotective effect of TRPM2 channels in diabetes-induced cognitive impairment. PMID: 32294037 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32294037?dopt=Abstract

Source: Current Neurovascular Research - April 14, 2020 Category: Neurology Authors: Thapak P, Bishnoi M, Sharma SS Tags: Curr Neurovasc Res Source Type: research