The Power of Delusion

Back in the Army when I was in the depths of undiagnosed schizophrenia, I wrote long letters asking my friends and family if they could see and feel what I was experiencing while stationed in the Mojave desert. I thought if I could persuade them to stare at a TV or computer screen and fixate on it, then they would be able to hear my voice, and I could hear theirs.  I tried to write everything that went through my mixed up mind into the letters I sent to my friends and family. For example, my brother was a cook at this restaurant at the time. In my mind, I thought I could see him driving and showing up to work. In the letters I might ask, “Could you feel my presence?” or “Do you remember seeing me?” I also thought if people made eye contact with me, they could instantly mentally connect with me,  and we could talk to each other without having to look at each other face to face. I could explain to them, through our telepathy, what was going on around me, and I thought it was possible for them to hear the same voices I was hearing inside my head.   Not everyone liked hearing the voices inside my head. I thought that one of my friends started sobbing when she was driving home because of all the voices she was hearing. I did my best to tell her it was going to be okay. I remember telling my aunt, who I thought was hearing my voices, that she could block some out if she just concentrated on her work or exercised.   The voices in...
Source: Psych Central - Category: Psychiatry Authors: Tags: Personal Stories Schizoaffective Disorder Schizophrenia Delusions positive symptoms Psychosis Source Type: news

Related Links:

In this study, β2∗ nAChR-containing receptors and lynx1 were identified using pull down studies from the mouse brain (Nissen et al., 2018), while ws-lynx1, SLURP-1 and SLURP-2 has been successfully mixed with human brain tissue to pull down multiple nAChR subtypes (Lyukmanova et al., 2016a,b; Thomsen et al., 2016). To support the in vivo interaction studies, a lynx1KO phenotype was ameliorated by crossing these mice into mutant mice null for α7 and β2 nAChR genes (Miwa et al., 2006). These in vivo studies provide an important biological context for the interactions observed within in vitro systems. ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusion Preclinical and clinical studies have demonstrated that treatment with antipsychotics and metformin had effects on the gut microbiota and the brain. Although the mechanism of the effects of metformin on AIMD remains unclear, there are some clues in the regulation of the gut-brain axis (Figure 1). The most important connections between metformin and AIMD in the gut microbiota were the mucin-degrading bacteria A. muciniphila and several SCFA-producing bacteria, such as the phyla Firmicutes and Bacteroidetes. The gut microbiota were was influenced during AIMD, and these changes included a decrease in A. muciniphil...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
We examined possible behavioral aberrations along three major symptom dimensions of schizophrenia including psychosis, social and emotional disruptions, and cognitive impairments. We detected significant gene–environment interactions in the amphetamine-induced locomotion in female animals and in the amphetamine-induced anxiety in male animals. Surprisingly, gene–environment interactions improved social memory in both male and female animals. JIA alone disrupted spatial memory and recognition memory, but only in male animals. DISC1 overexpression alone induced an improvement in sensorimotor gating, but only in f...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
It’s hardly news that the gastrointestinal tract is important to human health: It transports food from the mouth to the stomach, converts it into absorbable nutrients and stored energy, and shuttles waste back out of the body. If you don’t properly nourish yourself, you don’t live. It’s that simple. But in recent years, scientists have discovered that the GI system has an even bigger, more complex job than previously appreciated. It’s been linked to numerous aspects of health that have seemingly nothing to do with digestion, from immunity to emotional stress to chronic illnesses, including can...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Research Source Type: news
This study shows that some genetic changes linked to cancer are present in surprisingly large numbers of normal cells. We still have a long way to go to fully understand the implications of these new findings, but as cancer researchers, we can't underestimate the importance of studying healthy tissue." Early Onset of Menopause Correlates with Shorter Life Expectancy https://www.fightaging.org/archives/2018/10/early-onset-of-menopause-correlates-with-shorter-life-expectancy/ Aging is a phenomenon affecting all organs and systems throughout the body, driven by rising levels of molecular damage. The v...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: Available online 24 October 2018Source: Neuroscience LettersAuthor(s): Brittany F. Osborne, Alexandra Turano, Jasmine I. Caulfield, Jaclyn M. SchwarzAbstractEarly-life infection has been shown to have profound effects on the brain and behavior across the lifespan, a phenomenon termed “early-life programming”. Indeed, many neuropsychiatric disorders begin or have their origins early in life and have been linked to early-life immune activation (e.g. autism, ADHD, and schizophrenia). Furthermore, many of these disorders show a robust sex bias, with males having a higher risk of developing early-o...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
Corrigendum to "TRIMAGE: A dedicated trimodality (PET/MR/EEG) imaging tool for schizophrenia" [Eur Psychiatry 50 (2018) 7-20]. Eur Psychiatry. 2018 Jun;51:104-105 Authors: Del Guerra A, Ahmad S, Avram M, Belcari N, Berneking A, Biagi L, Bisogni MG, Brandl F, Cabello J, Camarlinghi N, Cerello P, Choi CH, Coli S, Colpo S, Fleury J, Gagliardi V, Giraudo G, Heekeren K, Kawohl W, Kostou T, Lefaucheur JL, Lerche C, Loudos G, Morrocchi M, Muller J, Mustafa M, Neuner I, Papadimitroulas P, Pennazio F, Rajkumar R, Brambilla CR, Rivoire J, Kops ER, Scheins J, Schimpf R, Shah NJ, Sorg C, Sportelli G, Tosetti M, ...
Source: Journal of the Association of European Psychiatrists - Category: Psychiatry Tags: Eur Psychiatry Source Type: research
CONCLUSION: We have developed a simple, rapid, and most efficient green protocol for the synthesis of 2-amino-4H-pyran derivatives using highly inexpensive and easily available DABCO as an efficient catalyst under grinding and solvent free condition at room temperature. Some of the synthesized compounds show good antimicrobial and anticancer activity. PMID: 29542410 [PubMed - as supplied by publisher]
Source: Combinatorial Chemistry and High Throughput Screening - Category: Chemistry Authors: Tags: Comb Chem High Throughput Screen Source Type: research
Publication date: Available online 1 February 2018 Source:European Psychiatry Author(s): Alberto Del Guerra, Salleh Ahmad, Mihai Avram, Nicola Belcari, Arne Berneking, Laura Biagi, Maria Giuseppina Bisogni, Felix Brandl, Jorge Cabello, Niccolò Camarlinghi, Piergiorgio Cerello, Chang-Hoon Choi, Silvia Coli, Sabrina Colpo, Julien Fleury, Vito Gagliardi, Giuseppe Giraudo, Karsten Heekeren, Wolfram Kawohl, Theodora Kostou, Jean-Luc Lefaucheur, Christoph Lerche, George Loudos, Matteo Morrocchi, Julien Muller, Mona Mustafa, Irene Neuner, Panagiotis Papadimitroulas, Francesco Pennazio, Ravichandran Rajkumar, Cláudi...
Source: European Psychiatry - Category: Psychiatry Source Type: research
Authors: Del Guerra A, Ahmad S, Avram M, Belcari N, Berneking A, Biagi L, Bisogni MG, Brandl F, Cabello J, Camarlinghi N, Cerello P, Choi CH, Coli S, Colpo S, Fleury J, Gagliardi V, Giraudo G, Heekeren K, Kawohl W, Kostou T, Lefaucheur JL, Lerche C, Loudos G, Morrocchi M, Muller J, Mustafa M, Neuner I, Papadimitroulas P, Pennazio F, Rajkumar R, Brambilla CR, Rivoire J, Kops ER, Scheins J, Schimpf R, Shah NJ, Sorg C, Sportelli G, Tosetti M, Trinchero R, Wyss C, Ziegler S, TRIMAGE Consortium Abstract Simultaneous PET/MR/EEG (Positron Emission Tomography - Magnetic Resonance - Electroencephalography), a new tool for t...
Source: Journal of the Association of European Psychiatrists - Category: Psychiatry Tags: Eur Psychiatry Source Type: research
More News: Computers | Gastroenteritis | Men | Psychiatry | Schizophrenia