An overview of parabens and allergic contact dermatitis.

An overview of parabens and allergic contact dermatitis. Skin Therapy Lett. 2013 Aug;18(5):5-7 Authors: Hafeez F, Maibach H Abstract Esters of p-hydroxybenzoic acid (parabens) are the most widely used preservatives in cosmetic, pharmaceutical, and industrial products. However, since the 1960s, controversy has surrounded its use and safety as a potential cause of allergic contact dermatitis. Despite the cloud of suspicion that has hovered over parabens ever since, these ubiquitous compounds have withstood four decades of extensive skin testing conducted by a variety of organizations, both North American and European, and now, it seems parabens have shown to be one of the least sensitizing preservatives in commercial use. Of the very limited reports of paraben-induced allergic contact dermatitis, these cases are often attributable to the application of parabens on damaged skin. PMID: 24305662 [PubMed - in process]
Source: Skin Therapy Letter - Category: Dermatology Authors: Tags: Skin Therapy Lett Source Type: research

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Conclusion: Head and neck cancer patients who undergo radiotherapy with curative indication are at risk for severe radiodermatitis. Nursing consultation is important to minimize the severity of this event and the reduction of temporary treatment interruption due to this adverse reaction.RESUMEN Objetivo: evaluar la asociaci ón entre los factores sociodemográficos, clínicos y de tratamiento en los resultados de la radiodermatitis grave en pacientes con cáncer de cuello y cabeza atendidos en una consulta de enfermería, además de analizar el efecto de los casos de radiodermatitis grav...
Source: Texto e Contexto - Enfermagem - Category: International Medicine & Public Health Source Type: research
Condition:   Atopic Dermatitis Interventions:   Drug: ATx201;   Drug: ATx201 OINTMENT vehicle Sponsor:   UNION therapeutics Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
BACKGROUND/OBJECTIVE: Skin diseases, especially those with visible manifestation, are considered to cause a major influence on global mental health. Therefore, we determined the prevalence and severity of anxiety, depression, and suicidal ideation in a lar...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
Conclusion: Spontaneous repigmentation occurs in one-fifth of patients with vitiligo. In some patients, the repigmentation is clinically significant and long-lasting. Considering its frequency and extent, spontaneous repigmentation should be taken into account both when evaluating novel interventions and counselling patients about the course of the disease.
Source: Indian Journal of Dermatology, Venereology and Leprology - Category: Dermatology Authors: Source Type: research
Abstract Mast cells are tissue-resident immune cells that are involved in inflammation and fibrosis but also serve beneficial roles, including tissue maintenance, angiogenesis, pathogen clearance, and immunoregulation. Their multifaceted response and the ability of their mediators to target multiple organs and tissues means that mast cells play important roles in numerous conditions, including asthma, atopic dermatitis, drug sensitivities, ischemic heart disease, Alzheimer disease, arthritis, irritable bowel syndrome, infections (parasites, bacteria and viruses), and cancer. As a result, mast cells have become an ...
Source: Journal of Immunology - Category: Allergy & Immunology Authors: Tags: J Immunol Source Type: research
This case report describes a 32-year-old woman with pruritic, small vesicles and papules on the eyelids, elbows, knees, buttocks, and scalp, as well as reddish-brown hemorrhagic lesions on the palms, soles, and volar surface of the fingers.
Source: JAMA Dermatology - Category: Dermatology Source Type: research
AbstractPatient-reported outcome (PRO) measures play an important role in clinical care. Currently, a broad-spectrum, validated PRO measure suitable for all dermatology patients, as part of clinical care, does not exist. Patient-reported Outcome Measures Information System (PROMIS) measures track specific domain outcomes across all diseases. To assess the relevance and utility of a computer-adaptive health assessment consisting of three PROMIS domains in routine dermatologic care. This retrospective study evaluated a PROMIS health assessment, consisting of three computer-adaptive test domains (pain interference, anxiety, a...
Source: Archives of Dermatological Research - Category: Dermatology Source Type: research
If you’re like most people trying to do their part in the midst of the COVID-19 outbreak, you’re washing your hands diligently with soap and water many times a day. Excellent hand hygiene is one essential public health measure to help stop the spread of the novel coronavirus. Unfortunately, additional handwashing can result in dry skin and hand dermatitis, a rash that can manifest as red, itchy, cracked, or sore skin. People who have a history of eczema or who are prone to dry skin may be even more likely to develop dry, chapped hands during this pandemic. What’s happening to your hands? Intact skin acts ...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Infectious diseases Skin and Hair Care Source Type: blogs
(North Carolina State University) A commonly expressed protein in skin -- periostin -- can directly activate itch-associated neurons in the skin, according to new research. Blocking periostin receptors on these neurons reduced the itch response in a mouse model of atopic dermatitis, or eczema.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
In conclusion, novel woad extracts were developed and shown to have anti-inflammatory properties in a contact hypersensitivity animal model and human keratinocytes. The production of such extracts and further characterization of their specific properties will enable determination of their potential dermatological effects in the treatment of inflamed and irritated skin. PMID: 32250439 [PubMed - as supplied by publisher]
Source: Acta Derm Venereol A... - Category: Dermatology Authors: Tags: Acta Derm Venereol Source Type: research
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