Treatment of infantile hemangiomas with Beta-blockers: a review.

Treatment of infantile hemangiomas with Beta-blockers: a review. Skin Therapy Lett. 2013 Oct;18(6):5-7 Authors: Shah S, Frieden IJ Abstract Infantile hemangiomas (IH) are the most common tumors occurring in early childhood, with a prevalence of approximately 5-10% of infants. While the natural history of IH is to spontaneously involute, a significant minority of IH require therapy with the aim to prevent disfigurement, functional impairment, or ulceration. In 2008, propranolol, a non-selective beta (β)-blocker, was reported to be highly effective in treating IH. Since that time there have been more than 200 articles published regarding the efficacy and potential toxicity of β-blockers, both systemic and topical, for the treatment of IH. Based on these finding, β-blockers appear to be highly effective in treating IH and are well tolerated, though side effects have been reported. When therapy is appropriately monitored, β-blockers have been proven to be a safer and superior alternative to systemic steroids. PMID: 24305730 [PubMed - in process]
Source: Skin Therapy Letter - Category: Dermatology Authors: Tags: Skin Therapy Lett Source Type: research

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We present the case of a 3-month-old baby who was brought to the Emergency Room for acute respiratory failure and dysphagia caused by the rapid increase in size of a soft palate and lateral pharyngeal wall tumor. The clinical examination revealed a "wine stain" hemangioma in the inter-eyebrow and frontal areas, a hemangioma in the right genial area, 1∕1.5 cm in diameter, growing rather in depth than on the surface, and a purplish-blue tumoral mass with irregular edges, grown in the soft palate and in the right lateral wall of the pharynx, which impaired both eating and breathing. Obstructive phenomena have been...
Source: Romanian Journal of Morphology and Embryology - Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research
AbstractHemangiomas are the most common benign tumors of the liver. These lesions are typically asymptomatic, solitary and almost always discovered incidentally, and in recent years with advances in imaging technology these lesions are being detected more frequently. Although, in majority of the cases, the imaging diagnosis of a liver hemangioma is clearly and confidently established, not all hemangiomas present with their characteristic or typical appearance on imaging. Occasionally, these lesions do present with an atypical pattern, and can be confused with other malignant lesions such as hepatocellular carcinoma, intrah...
Source: La Radiologia Medica - Category: Radiology Source Type: research
Conclusions: SWS affects approximately 0.19/100,000/year in Olmsted County. Early diagnosis, intervention, lifelong follow-up, and multidisciplinary approach should be used to optimize systemic and ocular outcomes. PMID: 32233696 [PubMed - as supplied by publisher]
Source: Ophthalmic Genetics - Category: Opthalmology Tags: Ophthalmic Genet Source Type: research
CONCLUSIONS: Because RCHs vary in size, the degree of inflammation, and symptoms, this disorder should be actively treated on a case-by-case basis. Fluorescein angiography should be used periodically to determine recurrence of the tumor or inflammation, and the appropriate treatment should be repeated as necessary. Moreover, regular systemic screening tests for von Hippel-Lindau disease should be performed in RCH patients to ensure that they have no abnormalities other than in the eye. PMID: 32233147 [PubMed - in process]
Source: Korean Journal of Ophthalmology : KJO - Category: Opthalmology Tags: Korean J Ophthalmol Source Type: research
In this report, we describe the case of a 58-year-old woman who presented with hematochezia and who was diagnosed with small bowel hemangioma. She was successfully treated using endoscopic sclerotherapy. Initial capsule endoscopy revealed bleeding in the ileum. Subsequent double-balloon enteroscopy showed a 2-cm, bluish-purple, ileal submucosal tumor with an overlying protrusion. The lesion was responsible for the hematochezia and was treated with intralesional injection of polidocanol. The hematochezia completely resolved and at 4 months after sclerotherapy, the size of the lesion was significantly reduced. PMID: 3223...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
We report a case of capillary hemangioma of lobular subtype in the calvarium of a 28-year-old pregnant woman which presented as a sore and rapidly growing bulge over the left fronto-parietal region. Magnetic resonance imaging of the brain and skull showed an expansive tumor with brain displacement, skull erosion, and scalp infiltration. The tumor was surgically removed, and histopathological examination showed a capillary hemangioma of lobular subtype. To the best of our knowledge, this is the first report of a lobular capillary hemangioma in the calvarium, and it represents a rarity to be considered among the many other d...
Source: Acta Neurochirurgica - Category: Neurosurgery Source Type: research
AbstractA 50 ‐ to 65‐year‐old female, from the Roman period Kellis 2 (K2) cemetery in the Dakhleh Oasis, Egypt, shows macroscopic and imaging evidence of a vertebral haemangioma (VH). The centrum of the 12th thoracic vertebrae has an expanded and lysed cortex and thickened vertical trabeculae—producing t he pathognomonic “corduroy” radiological sign. Additionally, the first lumbar vertebrae shows early changes of haemangioma that are not obvious macroscopically but clear on the X‐ray and the microcomputed tomography (μCT) imaging. VHs are relatively common (>10%) benign vascular tumours in e...
Source: International Journal of Osteoarchaeology - Category: Science Authors: Tags: RESEARCH ARTICLE Source Type: research
radRounds Radiology Network and Idonia are partnering to provide a professional Image Exchange Platform to facilitate collaboration, exchange and research on COVID-19 cases.Users can upload, store, organize, review, and share DICOM Images.Idonia is a secure (HIPAA compliant) online platform for medical image exchange and delivery. The platform can serve as a repository for relevant clinical cases, which radiologists can access and visualize thanks to the DICOM viewer of the platform. This allows radiologists to create their own network to collaborate and share relevant cases with other radiologists.Idonia and radRounds hav...
Source: radRounds - Category: Radiology Authors: Source Type: blogs
Conclusion: The response to propranolol treatment in IH patients was associated with the gene polymorphism of CYP2D6 (rs1135840). A low-dose propranolol regimen was effective and safe in young infants with IH. The change of serum VEGF levels after one month's treatment could not be used to predict the response rate to propranolol. PMID: 32219146 [PubMed - as supplied by publisher]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Epigenomics, Ahead of Print.
Source: Future Medicine: Epigenomics - Category: Genetics & Stem Cells Authors: Source Type: research
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