Selected skin diseases with systemic involvement.
Selected skin diseases with systemic involvement. Skin Therapy Lett. 2013 Jun;18(4):1-4 Authors: Ruiz M, Valdés P, Tomecki K Abstract The skin is often a window to systemic disease that is available to the trained eye of the dermatologist. Herein, we focus on four dermatoses with associated systemic conditions of interest: scleromyxedema and monoclonal gammopathy, nephrogenic systemic fibrosis in the setting of renal insufficiency, dermatitis herpetiformis and celiac disease, and psoriasis as a risk factor for cardiovascular disease. Dermatologists can play a crucial role in recognizing the cutaneous manifestations linked with these conditions. Identifying the related underlying disorder will contribute to appropriate diagnosis and improved management. PMID: 24310641 [PubMed - in process]
Conditions: Alopecia Areata; Depressive Episode; Recurrent Depressive Disorder; Anxiety Disorders; Atopic Dermatitis; Allergic Rhinitis; Asthma; Crohn Disease; Ulcerative Colitis; Pernicious Anemia; Type 1 Diabetes; Hashimoto Thyroiditis; Graves Disease; Rheumatoid Arthritis; Psoriatic Arthritis; Ankylosing Spondylitis; Systemic Lupus Erythematosus; Polymyalgia Rheumatica; Sjogren's Syndro...
CONCLUSIONS: At adolescence, both Crohn's disease and ulcerative colitis are associated with multiple comorbidities, not limited to autoimmune disorders. PMID: 31801156 [PubMed - as supplied by publisher]
Conclusions: CD patients with family history of AD, overweight at CD diagnosis, and a delay of CD diagnosis had an increased risk of having another AD. The benefit of CD screening in these specific subsets of patients with AD awaits further investigation. PMID: 30275824 [PubMed]
In conclusion, the novelty of this matter has generated an expansion of literature data with the unavoidable consequence that some reports are often based on low levels of evidence. Therefore, only studies performed on large samples with the inclusion of control groups will be able to clearly establish whether the large information from the literature regarding extra-intestinal NCGS manifestations could be supported by evidence-based agreements. PMID: 29662290 [PubMed - in process]
Conclusion: Under normal circumstances, keratinocytes overexpress elafin to downregulate a neutrophil mediated inflammatory response. The deficient expression of elafin in the aforementioned probed DH specimens correlates with previous similar elafin underexpression in intestinal samples of active CD. These histological findings suggest that these 2 gluten mediated disorders carry an abnormal elafin underexpression during disease activity.
To the Editor: Alopecia areata (AA) is a common, polygenic, T-lymphocyte-mediated nonscarring hair loss.1 It has been associated with atopic dermatitis, allergic rhinitis, lupus erythematosus, psoriasis, thyroid disease, rheumatoid arthritis, celiac disease, and type 1 diabetes mellitus.1-3 This research letter represents a review of Cleveland Clinic Alopecia Registry to assess comorbidities present in patients given a diagnosis of AA. To identify these comorbidities, we performed a retrospective chart review.
Director chair, film slate and load horn. Here’s a proposal for you: If, by following the Wheat Belly lifestyle, a long list of conditions are reduced or reversed at no risk, almost no cost, reversing even chronic and potentially fatal conditions . . . does that mean that the notion of self-directed health might be on the horizon, i.e., putting control over health back in our own hands? I think it does. No, we will never implant our own defibrillators or take out our own gallbladders. But so many chronic health conditions afflicting modern humans recede that I believe that it is entirely reasonable to start talking a...
Rick shared the progression of facial and health changes he experienced by following the Wheat Belly lifestyle (above). Since he began 5 months ago, Rick has lost 28 pounds and 8 inches off his waist, he is freed from previously chronic knee and back pain, and experienced an improvement in mood. But take a look at Rick’s photos when we put his most recent photo at 248.6 pounds up against his 2009 photo at a weight of 250 pounds–virtually the same weight: Even though each photo was taken at similar weight, look at the impressive contrast in Rick’s face: The photos look like two different people at virtual...