Evidence for communication of peripheral iron status to cerebrospinal fluid: clinical implications for therapeutic strategy

ConclusionsThe clinical ramifications of these findings are several- fold. They suggest that erythropoietic demands for iron take precedence over brain requirements, and that the metric traditionally considered to be the most specific test reflecting total body iron stores and relied upon to inform treatment decisions –i.e., serum ferritin –may not be the preferred peripheral indicator when attempting to promote brain iron uptake. The future direction of this line of investigation is to identify the factor(s) in the CSF that influence iron transport at the level of the BBB.
Source: Fluids and Barriers of the CNS - Category: Neuroscience Source Type: research