[ 18 F]Atorvastatin: synthesis of a potential molecular imaging tool for the assessment of statin-related mechanisms of action
ConclusionsThe improved ruthenium-mediated18F-deoxyfluorination procedure overcomes previous hurdles such as the addition of salt additives, the drying steps, or the use of different solvent mixtures at different phases of the process, which increases its practical use, and may allow faster translation to clinical settings. Based on tissue uptake evaluations, [18F]atorvastatin showed the potential to be used as a tool for the understanding of the mechanism of action of statins. Further knowledge of the in vivo biodistribution of [18F]atorvastatin may help to better understand the origin of off-target effects and potentially allow to distinguish between statin-resistant and non-resistant patients.
Source: EJNMMI Research - Category: Radiology Source Type: research
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