PERK/NRF2 and autophagy form a resistance mechanism against G9a inhibition in leukemia stem cells

The histone methyltransferase G9a has recently been identified as a potential target for epigenetic therapy of acute myeloid leukemia (AML). However, the effect of G9a inhibition on leukemia stem cells (LSCs),...

Source: Journal of Experimental and Clinical Cancer Research - April 15, 2020 Category: Cancer & Oncology Authors: Ji Eun Jang, Ju-In Eom, Hoi-Kyung Jeung, Haerim Chung, Yu Ri Kim, Jin Seok Kim, June-Won Cheong and Yoo Hong Min Tags: Research Source Type: research