FASpecT/CT, A New SPECT/CT Acquisition With Higher Sensitivity and Efficiency in Radioiodine Thyroid Cancer Imaging

Conclusions This FASpecT/CT acquisition in radioiodine-treated DTC offers the potential of higher sensitivity for metastatic lymph node detection in low count rates and a significant decrease in imaging time in high count rates. These advantages make SPECT/CT imaging more acceptable for patients who have difficulty with longer imaging times, to include the pediatric population.
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Original Articles Source Type: research

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In this study, scintigraphy and single-photon emission computed tomography/computed tomography images after radioactive iodine treatment revealed a physiological uptake of radioactive iodine due to lacrimal secretion around an artificial eyeball; such findings have not been reported previously.
Source: Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
Conclusion: In papillary thyroid carcinoma I-131 post-ablation SPECT/CT scan detects cervical lymphadenopathy and predicts relapse by NM stage more accurately than WBS.
Source: In Vivo - Category: Research Authors: Tags: Clinical Studies Source Type: research
CONCLUSIONS: Technique is important to maximize information obtained from radioiodine scans of patients with DTC. With the greater usage and understanding of these seven techniques, physicians will significantly improve the information obtained from a radioiodine scan in patients with DTC, which in turn may alter management and potentially outcomes. PMID: 31184275 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
157Objectives: Neuroblastoma is the most common extracranial tumors in children, and about half of patients have metastatic disease at presentation (1, 2). I-123-MIBG has been recognized as a radiopharmaceutical of choice in neuroblastoma assessment (3, 4). In recent years, promising diagnostic results are reported by F-18-FDOPA PET-CT after 60-90 min of radiopharmaceutical injection (delay F-18-FDOPA PET-CT) (5, 6). Early F-18-FDOPA PET-CT (3-30 min scan after radiopharmaceutical injection) showed better diagnostic performance in medullary thyroid cancer and brain tumor (7, 8), however, it has not been studied in neurobla...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Pediatrics Source Type: research
Conclusions Detection of regional and distant metastases on postoperative Dx scans permits adjustment of prescribed 131I activity for targeted treatment, as compared with fixed-activity ablation. This approach resulted in complete response after a single 131I treatment in 88% patients with histopathologic risk factors and regional metastases and 42% patients with distant metastases. Most patients with structural incomplete response (81%) had elevated thyroglobulin levels with negative follow-up 131I scans and positive PET/CT and/or CT scans consistent with altered tumor biology (non–iodine-avid disease).
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Original Articles Source Type: research
Sodium/iodide symporter (NIS)-mediated iodide uptake in thyroid follicular cells is the basis of clinical utilization of radioiodines. The cloning of the NIS gene enabled applications of NIS as a reporter gene in both preclinical and translational research. Non-invasive NIS imaging with radioactive iodides and iodide analogs has gained much interest in recent years for evaluation of thyroid cancer and NIS reporter expression. Although radioiodines and [99mTc]pertechnetate ([99mTc]TcO4-) have been utilized in positron emission tomography (PET) and single photon emission computed tomography (SPECT), they may suffer from limi...
Source: Theranostics - Category: Molecular Biology Authors: Tags: Review Source Type: research
Conclusions99mTc-sestamibi may have a role in thyroid cancer localization when physical exam, neck ultrasound, radioiodine scan, chest/abdomen CT, and18F-FDG PET/CT does not identify the source of elevated Tg levels in DTC.
Source: Endocrine - Category: Endocrinology Source Type: research
Abstract The term theranostics is the combination of a diagnostic tool that helps to define the right therapeutic tool for specific disease. It signifies the "we know which sites require treatment (diagnostic scan) and confirm that those sites have been treated (post therapy scan)" demonstrating the achievable tumor dose concept. This term was first used by John Funkhouser at the beginning of the 90's at the same time the concept of personalized medicine appeared. In nuclear medicine theranostics is easy to apply and understand because of an easy switch from diagnosis to therapy with the same vector. It ...
Source: The British Journal of Radiology - Category: Radiology Authors: Tags: Br J Radiol Source Type: research
Conclusions99mTc-sestamibi may have a role in thyroid cancer localization when physical exam, neck ultrasound, radioiodine scan, chest/abdomen CT, and18F-FDG PET/CT does not identify the source of elevated Tg levels in DTC.
Source: Endocrine - Category: Endocrinology Source Type: research
CONCLUSION: Our findings suggested that 99mTc WBS is a useful imaging modality in detecting remnant thyroid tissue, nodal and distant metastases before 131I therapy. The additional SPET/CT scan when needed in 18 cases supported the 99mTc WBS diagnosis. PMID: 30089313 [PubMed - in process]
Source: Hellenic Journal of Nuclear Medicine - Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research
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