Functionalization of Alkenyl C –H Bonds with D2O via Pd(0)/Carboxylic Acid Catalysis

We report herein a simple catalytic method for the extensive labeling of alkenyl C–H bonds through the combination of a palladium(0) complex and a carboxylic acid in the presence of deuterium oxide. The reaction can be applied to a variety of terminal alkenes and the best results are obtained with aryl-substituted examples. This method represents a convenient approach for the preparation of extensively labeled chemicals from the cheapest and safest source of deuterium. [...] © Georg Thieme Verlag Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Synthesis - April 13, 2020 Category: Chemistry Authors: Camedda, Nicola Serafino, Andrea Maggi, Raimondo Bigi, Franca Cera, Gianpiero Maestri, Giovanni Tags: feature Source Type: research