Pathophysiology of AKI to CKD progression

Summary: Acute kidney injury (AKI), defined as a rapid decrease in glomerular filtration rate, is a common and devastating pathologic condition. AKI is associated with significant morbidity and subsequent chronic kidney disease (CKD) development. Regardless of the initial insult, CKD progression after AKI involves multiple types of cells, including proximal tubular cells, fibroblasts, and immune cells. Although the mechanisms underlying this AKI to CKD progression have been investigated extensively over the past decade, therapeutic strategies still are lacking.

Source: Seminars in Nephrology - February 29, 2020 Category: Urology & Nephrology Authors: Yuki Sato, Masahiro Takahashi, Motoko Yanagita Source Type: research