Phospho-proteomic discovery of novel signal transducers including thioredoxin-interacting protein as mediators of erythropoietin-dependent human erythropoiesis

The production of erythroid progenitors requires signals provided by erythropoietin (EPO) and its JAK2-coupled receptor, EPOR [1]. Recombinant human (rh)EPO and related EPOR agonists are also important therapeutics for the anemia of chronic kidney disease [2], myelodysplastic syndrome [3], and chemotherapy [4]. While EPO actions have accordingly been intensely studied [5,6], an advanced understanding of EPO/EPOR/JAK2 effects is important for several reasons. Clinically, and via poorly understood mechanisms, EPO also elicits hypertensive and thrombolytic side effects [7].

Source: Experimental Hematology - April 3, 2020 Category: Hematology Authors: Matthew A. Held, Emily Greenfest-Allen, Edward Jachimowicz, Christian J. Stoeckert, Matthew P. Stokes, Antony W. Wood, Don M. Wojchowski Tags: Regular submission Source Type: research