Comparison of Neonatal and Adult Fibrin Clot Properties between Porcine and Human Plasma
Conclusions The authors identified similar age-related patterns in structure, mechanical, and degradation properties between adults and neonates in porcine and human samples. These findings suggest that piglets are an appropriate preclinical model of neonatal coagulopathy. The authors also show the feasibility ofin vitro model application through analysis of novel hemostatic therapies as applied to dilute neonatal porcine plasma.Editor ’s PerspectiveWhat We Already Know about This TopicNeonatal fibrinogen exists in a fetal form until maturation and is structurally and functionally distinct from adult fibrinogenReplacement of neonatal fibrinogen with adult fibrinogen after cardiopulmonary bypass may lead to inconsistent efficacy in treating postcardiopulmonary bypass bleedingThe hemostatic system of pigs is similar to that of humansWhat This Article Tells Us That Is NewFibrinogen concentration and functionality in plasma collected from piglets paralleled those observed in plasma collected from human neonatesFibrin network structure was highly aligned in both neonatal species and highly branched in adults of both speciesFibrin network stiffness and degradation patterns in both neonatal species were substantially similar as they were in adults of both speciesTheex vivo addition of several procoagulant therapies augmented fibrin network properties of diluted piglet plasma
Source: Anesthesiology - Category: Anesthesiology Source Type: research
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