Sevoflurane and Parkinson ’s Disease Subthalamic Nucleus Neuronal Activity and Clinical Outcome of Deep Brain Stimulation

Conclusions Sevoflurane general anesthesia decreased beta-frequency oscillations by inducing coherent lower frequency oscillations, comparable to the pattern seen in the scalp electroencephalogram. Nevertheless, sevoflurane-induced changes in electrical activity patterns did not reduce electrode placement accuracy and clinical effect. These observations suggest that microelectrode-guided deep brain stimulation under sevoflurane anesthesia is a feasible clinical option.Editor ’s PerspectiveWhat We Already Know about This TopicAccurate stimulating electrode placement is essential for clinically effective subthalamic nucleus brain stimulation in patients with Parkinson ’s diseaseGeneral anesthetics-induced changes of electrical oscillations in the basal ganglia may render the identification of the stimulation targets difficultThe effects of sevoflurane-based general anesthesia on the electrophysiologic properties of subthalamic neurons, electrode placement efficacy, and long-term clinical outcomes in Parkinson ’s disease have not been previously reportedWhat This Article Tells Us That Is NewWhen compared to local anesthesia, sevoflurane-based general anesthesia decreased beta-frequency oscillations and induced coherent lower frequency oscillations in the subthalamic nucleus of patients with Parkinson ’s disease undergoing electrode placement for deep brain stimulationThese sevoflurane-induced changes in electrical activity patterns did not reduce electrode placement accu...
Source: Anesthesiology - Category: Anesthesiology Source Type: research