Luminex screening first vs. direct single antigen bead assays: Different strategies for HLA antibody monitoring after kidney transplantation.

CONCLUSIONS: Luminex screening failed to identify clinically relevant HLA antibodies, hampering DSA detection in patients with possible ABMR. Direct SAB testing should be the chosen strategy for post-transplantation monitoring, albeit direct SAB from the two existing manufacturers may diverge in as much as 50% of cases. PMID: 32279925 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32279925?dopt=Abstract

Source: Human Immunology - April 8, 2020 Category: Allergy & Immunology Authors: Burballa C, Pérez-Saéz MJ, Redondo-Pachón D, García C, Mir M, Arias-Cabrales C, Valenzuela NM, Reed EF, Pascual J, Crespo M Tags: Hum Immunol Source Type: research