Research provides new insights into menopause and weight gain
Can women in menopause get the benefits of hormone replacement therapy without the risks? Anew UCLA study conducted with mice points in that direction, but additional research is necessary.Women commonly experience hot flashes and weight gain, among other changes, during and after menopause. Hormone therapy, which gives women additional estrogen, can help alleviate some of these symptoms, but it has been linked to a higher risk of heart disease and breast cancer.UCLA life scientists now report that a gene called reprimo, which is expressed by certain neurons in the brain, may play a role in menopause-related weight gain, a phenomenon not linked to increased eating. Their findings are published today in the journal Nature Metabolism.“We want to figure out which neurons are mediating the beneficial portions of hormone therapy and mimic them without hormones,” said senior author Stephanie Correa, a UCLA assistant professor of integrative biology and physiology and a member ofUCLA's Brain Research Institute. “Hormone therapy can be beneficial, but it treats the entire brain and body with hormones. We may be able to bypass the hormone. That’s our goal, and it's a big one. We haven't achieved it yet, but we're learning.”Correa and her research team show that the reprimo gene is important for regulating temperature. Changes in temperature are known to affect body weight and may contribute to the weight gain often seen in menopause.&ldquo...
Authors: Brand C, Sehn AP, Gaya AR, Mota J, Brazosayavera J, Pollo Renner JD, Reuter CP Abstract PURPOSE: To verify the moderator role of physical fitness in the relationship betweenadiposity and cardiometabolic risk factors in normal weight and overweight/obese children and adolescents. METHODS: Cross-sectional study comprising 2482 children and adolescents, aged 7-17 years. Physical fitness was evaluated according the procedures of Projeto Esporte Brazil, and waist circumference (WC) with an inelastic tape. Cardiometabolic risk score was defined by the z-score sum of glucose, total cholesterol, high-density l...
Authors: Latha S, Selvamani P, Prabha T Abstract Natural products have a unique place in the healthcare industry. The genus Commiphora emerged as a potential medicinal with huge benefits as evidenced through its use in various traditional and modern systems of medicine. Therefore, we aimed to prepare a concise review on the pharmacological activities and the indigenous uses of various plant species belonging to the genus Commiphora along with the structural information of various active botanical ingredients present in these plants based on the published literatures and scientific reports. To collect the various pu...
Publication date: Available online 3 July 2020Source: European UrologyAuthor(s): Giuseppe Di Lorenzo, Riccardo Autorino
Publication date: Available online 3 July 2020Source: European UrologyAuthor(s): Christian D. Fankhauser, Kathryn L. Penney, Amparo G. Gonzalez-Feliciano, Noel W. Clarke, Thomas Hermanns, Konrad H. Stopsack, Michelangelo Fiorentino, Massimo Loda, Brandon Mahal, Travis A. Gerke, Mark A. Preston, Lorelei A. Mucci
Publication date: Available online 3 July 2020Source: European UrologyAuthor(s): David E. Neal, Chris Metcalfe, Jenny L. Donovan, J. Athene Lane, Michael Davis, Grace J. Young, Susan J. Dutton, Eleanor I. Walsh, Richard M. Martin, Tim. J. Peters, Emma L. Turner, Malcolm Mason, Richard Bryant, Prasad Bollina, James Catto, Alan Doherty, David Gillatt, Vincent Gnanapragasam, Peter Holding, Owen Hughes
Publication date: Available online 2 July 2020Source: European UrologyAuthor(s): Carlo A. Bravi, Nicola Fossati, Giorgio Gandaglia, Nazareno Suardi, Elio Mazzone, Daniele Robesti, Daniar Osmonov, Klaus-Peter Juenemann, Luca Boeri, R. Jeffrey Karnes, Alexander Kretschmer, Alexander Buchner, Christian Stief, Andreas Hiester, Alessandro Nini, Peter Albers, Gaëtan Devos, Steven Joniau, Hendrik Van Poppel, Shahrokh F. Shariat
Publication date: Available online 2 July 2020Source: European UrologyAuthor(s): Alexandre R. Zlotta, Sigrid V. Carlsson, Antonio Finelli, Neil E. Fleshner
Publication date: Available online 2 July 2020Source: European UrologyAuthor(s): Francesco Massari, Veronica Mollica
Publication date: Available online 2 July 2020Source: European UrologyAuthor(s): Philip Cornford, Jeremy Grummet, Stefano Fanti, on behalf of the EAU-EANM-ESTRO-ESUR-SIOG Prostate Cancer Guidelines Panel
In conclusion, this study suggests that epigenetic age acceleration is significantly associated with lung function in women older than 50 years. We hypothesised that this could be due to menopause. However, we have observed that menopause has minimal effect and therefore there is possibility of other unknown physiological factors at older age in females mediating the epigenetic age acceleration effect on lung function. While, it is still unknown what exactly epigenetic aging from DNA methylation measures, this study suggests it can be utilised as one of the important factors to assess women's lung health in old age. DNA me...
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